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Shane Crotty's biography of David Baltimore details the life and work of one of the most brilliant, powerful, and controversial scientists of our time. Although only in his early sixties, Baltimore has made major discoveries in molecular biology, established the prestigious Whitehead Institute at MIT, been president of Rockefeller University, won the Nobel Prize, and been vilified by detractors in one of the most scandalous and protracted investigations of scientific fraud ever. He is now president of Caltech and a leader in the search for an AIDS vaccine. Crotty not only tells the compelling story of this larger-than-life figure, he also treats the reader to a lucid account of the amazing revolution that has occurred in biology during the past forty years.
Basing his narrative on many personal interviews, Crotty recounts the milestones of Baltimore's career: completing his Ph.D. at Rockefeller University in eighteen months, participating in the anti—Vietnam War movement, winning a Nobel Prize at age thirty-seven for the codiscovery of reverse transcriptase, and co-organizing the recombinant DNA/genetic engineering moratorium. Along the way, readers learn what viruses are and what they do, what cancer is and how it happens, the complexities of the AIDS problem, how genetic engineering works, and why making a vaccine is a complicated process. And, as Crotty considers Baltimore's public life, he retells the famous scientific fraud saga and Baltimore's vindication after a decade of character assassination.
Crotty possesses the alchemical skill of converting technical scientific history into entertaining prose as he conveys Baltimore's huge ambitions, intensity, scientific genius, attitude toward science and politics, and Baltimore's own view about what happened in the "Baltimore Affair." Ahead of the Curve shows why with his complex personality, keen involvement in public issues, and wide-ranging interests David Baltimore has not only shaped the face of American science as we know it today, but has also become a presence in our culture.
- Sales Rank: #1500488 in Books
- Published on: 2003-06-02
- Original language: English
- Number of items: 1
- Dimensions: 9.02" h x .64" w x 5.98" l, 1.07 pounds
- Binding: Paperback
- 270 pages
From Publishers Weekly
Nobel Prize winner Baltimore has had a remarkable influence on 20th-century biology. As one colleague has stated, "It is not an exaggeration to say that one could write a pretty decent history of the last 25 years in biology by reviewing Dr. Baltimore's contributions." Indeed, Baltimore has made significant discoveries in molecular biology, been actively involved in cancer and AIDS research, was the founding director of the Whitehead Institute for Biomedical Research at MIT, was president of Rockefeller University, is currently president of the California Institute of Technology and was at the center of the nation's most protracted and public examination of scientific fraud. Crotty, a doctoral fellow at UC-San Francisco, does an impressive job of outlining Baltimore's scientific role in many of his major discoveries and makes many of the basics of modern molecular biology accessible to the general public. What is missing, however, is any deep sense of Baltimore. We see many of his actions and his experiments but we never fully come to know the individual. His personal life is almost entirely undisclosed, as are the reasons why a significant portion of the scientific establishment turned on him amid the accusations of fraud, of which he was ultimately cleared. Nonetheless, readers wanting to gain insight into the politics of contemporary science and those with a particular interest in microbiology, cancer and AIDS research will not be disappointed. Photos not seen by PW.
Copyright 2001 Cahners Business Information, Inc.
From Library Journal
When hearing David Baltimore's name, many people will think only of the ten-year scientific fraud scandal involving him and Thereza Imanishi-Kari. Yet Baltimore has been an important figure in modern molecular biology and virology, from his early work on RNA replicase and animal virus replication and his role in the controversy surrounding early recombinant DNA experientments, to his continuing work at Caltech as its president and as head of the AIDS Vaccine Research Committee. Crotty, Howard Hughes Doctoral Fellow at the University of California, San Francisco, has written an intriguing biography of the controversial Nobel Prize-winning scientist. She narrates Baltimore's life in the context of the exciting discoveries that have changed biology since the 1950s and the fascinating people who made those discoveries and influenced Baltimore's career. Crotty also takes the time to explain clearly the science and scientific methods used in molecular biology and virology research. She covers the fraud case well, but David Kevles's The Baltimore Case: A Trial of Poltics, Science, and Character (LJ 10/1/98) offers a more extended study of that event. For public and academic libraries. Margaret Henderson, Cold Spring Harbor Academics, NY
Copyright 2001 Reed Business Information, Inc.
Review
"When David Baltimore entered biology, the molecular revolution was over: now the goal was to unravel molecular complexity, not to prove its existence. In this highly readable book, Crotty shows how efficiently Baltimore did precisely that."--"American Scientist
Most helpful customer reviews
3 of 3 people found the following review helpful.
When Baltimore speaks, everyone listens.
By A Customer
I truly enjoyed reading this book on the impressive scientific accomplishments of David Baltimore. I remember being in a relatively informal seminar at MIT when he gave a short introduction to the science that was to be presented that evening. His presence commanded awe and respect---almost always expected from someone with outstanding credentials.
The book is good not just for examining Baltimore's exponential rise to scientific stardom but also for getting a seminal idea on the development of the fields of virology, molecular biology, and immunology. Through his work, Baltimore became a unifying force between these seemingly disparate sciences. The author also writes clearly about the political baggage that comes with having such a high profile in biology.
3 of 3 people found the following review helpful.
No rule without an exception
By Dr. Hiroshi Maruta
In 1950s, Watson and Crick established a so-called "central dogma" in molecular biology: DNA makes RNA, and RNA makes proteins. However, around 1970, two groups in US found the first exception of this rule. David Baltimore's and Howard Temin's teams discovered that RNA makes DNA! This unexpected finding of theirs in cancer-causing RNA viruses not only made this field up-side down, but also opened a new avenue called "recombinant technology" a decade later, for cloning genes and transfering any gene from one species to another almost at will. For this reason, Baltimore and Temin shared a Nobel prize in 1975. Baltimore's greatness extended beyond the science. He viewed this world in an "unconventional" manner. He married a highly-talented Chinese biologist, and protested against the highly controversial US wars in Vietnam and Iraq. He has an exceptional wisdom which we could learn from this well-written biography.
8 of 9 people found the following review helpful.
A Must Read!
By A Customer
The author weaves a wonderful overview of the early history of molecular biology with the achievements of David Baltimore's life. We are given a great deal of insight not only about his groundbreaking research and accomplishments but also personal qualities and passion for life outside of science.
This is a great book for both biologists and those with simply an interest in biology. The scientific information is easy to comprehend without being oversimplified.
Some works of non-fiction can take a long time to read, but I finished this book in 2 days as the story flowed very smoothly. I am definitely looking forward to Shane Crotty's future publications.
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